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10.7554/eLife.18311 http://scihub22266oqcxt.onion/10.7554/eLife.18311 C5028189!5028189!27525483     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27525483&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27525483.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       eLife 2016 ; 5 (ä): ä Nephropedia Template TP {{tp|p=27525483|t=2016. A systematic view on influenza induced host shutoff |pdf=|usr=}}{{27525483}} gab.com Text A systematic view on influenza induced host shutoff JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=27525483 #FOAvip Host shutoff is a common strategy used by viruses to repress cellular mRNA translation and concomitantly allow the efficient translation of viral mRNAs. Here we use RNA-sequencing and ribosome profiling to explore the mechanisms that are being utilized by the Influenza A virus (IAV) to induce host shutoff. We show that viral transcripts are not preferentially translated and instead the decline in cellular protein synthesis is mediated by viral takeover on the mRNA pool. Our measurements also uncover strong variability in the levels of cellular transcripts reduction, revealing that short transcripts are less affected by IAV. Interestingly, these mRNAs that are refractory to IAV infection are enriched in cell maintenance processes such as oxidative phosphorylation. Furthermore, we show that the continuous oxidative phosphorylation activity is important for viral propagation. Our results advance our understanding of IAV-induced shutoff, and suggest a mechanism that facilitates the translation of genes with important housekeeping functions.DOI:http://dx.doi.org/10.7554/eLife.18311.001 Twit Text FOAVip A systematic view on influenza induced host shutoff ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=27525483 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27525483 #FOAvip English Wikipedia <ref>{{Cite pmid|27525483}}</ref> A systematic view on influenza induced host shutoff #MMPMID27525483 Bercovich-Kinori A; Tai J; Gelbart IA; Shitrit A; Ben-Moshe S; Drori Y; Itzkovitz S; Mandelboim M; Stern-Ginossar N eLife 2016[]; 5 (ä): ä PMID27525483show ga Host shutoff is a common strategy used by viruses to repress cellular mRNA translation and concomitantly allow the efficient translation of viral mRNAs. Here we use RNA-sequencing and ribosome profiling to explore the mechanisms that are being utilized by the Influenza A virus (IAV) to induce host shutoff. We show that viral transcripts are not preferentially translated and instead the decline in cellular protein synthesis is mediated by viral takeover on the mRNA pool. Our measurements also uncover strong variability in the levels of cellular transcripts reduction, revealing that short transcripts are less affected by IAV. Interestingly, these mRNAs that are refractory to IAV infection are enriched in cell maintenance processes such as oxidative phosphorylation. Furthermore, we show that the continuous oxidative phosphorylation activity is important for viral propagation. Our results advance our understanding of IAV-induced shutoff, and suggest a mechanism that facilitates the translation of genes with important housekeeping functions.DOI:http://dx.doi.org/10.7554/eLife.18311.001 äA systematic view on influenza induced host shutoff (epmc).pdf DeepDyve Pubget Overpricing