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10.1152/ajpendo.00371.2013 http://scihub22266oqcxt.onion/10.1152/ajpendo.00371.2013 C3989739!3989739 !24518676     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24518676 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24518676 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Endocrinol+Metab 2014 ; 306 (8 ): E854-68 Nephropedia Template TP {{tp|p=24518676 |t=2014. A systematic survey of lipids across mouse tissues |pdf=|usr=}}{{24518676 }} gab.com Text A systematic survey of lipids across mouse tissues JO: Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=24518676 #FOAvip Lipids are a diverse collection of macromolecules essential for normal physiology, but the tissue distribution and function for many individual lipid species remain unclear. Here, we report a mass spectrometry survey of lipid abundance across 18 mouse tissues, detecting ~1,000 mass spectrometry features, of which we identify 179 lipids from the glycerolipids, glycerophospholipids, lysophospholipids, acylcarnitines, sphingolipids, and cholesteryl ester classes. Our data reveal tissue-specific organization of lipids and can be used to generate testable hypotheses. For example, our data indicate that circulating triglycerides positively and negatively associated with future diabetes in humans are enriched in mouse adipose tissue and liver, respectively, raising hypotheses regarding the tissue origins of these diabetes-associated lipids. We also integrate our tissue lipid data with gene expression profiles to predict a number of substrates of lipid-metabolizing enzymes, highlighting choline phosphotransferases and sterol O-acyltransferases. Finally, we identify several tissue-specific lipids not present in plasma under normal conditions that may be of interest as biomarkers of tissue injury, and we show that two of these lipids are released into blood following ischemic brain injury in mice. This resource complements existing compendia of tissue gene expression and may be useful for integrative physiology and lipid biology. Twit Text FOAVip A systematic survey of lipids across mouse tissues ????Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=24518676 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24518676 #FOAvip English Wikipedia <ref>{{Cite pmid|24518676 }}</ref> A systematic survey of lipids across mouse tissues #MMPMID24518676 Jain M ; Ngoy S ; Sheth SA ; Swanson RA ; Rhee EP ; Liao R ; Clish CB ; Mootha VK ; Nilsson R Am J Physiol Endocrinol Metab 2014[Apr]; 306 (8 ): E854-68 PMID24518676 show ga Lipids are a diverse collection of macromolecules essential for normal physiology, but the tissue distribution and function for many individual lipid species remain unclear. Here, we report a mass spectrometry survey of lipid abundance across 18 mouse tissues, detecting ~1,000 mass spectrometry features, of which we identify 179 lipids from the glycerolipids, glycerophospholipids, lysophospholipids, acylcarnitines, sphingolipids, and cholesteryl ester classes. Our data reveal tissue-specific organization of lipids and can be used to generate testable hypotheses. For example, our data indicate that circulating triglycerides positively and negatively associated with future diabetes in humans are enriched in mouse adipose tissue and liver, respectively, raising hypotheses regarding the tissue origins of these diabetes-associated lipids. We also integrate our tissue lipid data with gene expression profiles to predict a number of substrates of lipid-metabolizing enzymes, highlighting choline phosphotransferases and sterol O-acyltransferases. Finally, we identify several tissue-specific lipids not present in plasma under normal conditions that may be of interest as biomarkers of tissue injury, and we show that two of these lipids are released into blood following ischemic brain injury in mice. This resource complements existing compendia of tissue gene expression and may be useful for integrative physiology and lipid biology. |*Lipid Metabolism [MESH] |*Metabolome [MESH] |Adiposity [MESH] |Animal Structures/*chemistry/metabolism [MESH] |Animals [MESH] |Chromatography, Liquid [MESH] |Cluster Analysis [MESH] |Lipids/*analysis [MESH] |Male [MESH] |Mass Spectrometry [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH]A systematic survey of lipids across mouse tissues (epmc).pdf DeepDyve Pubget Overpricing