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A subspace approach to high-resolution spectroscopic imaging
#MMPMID24496655
Lam F
; Liang ZP
Magn Reson Med
2014[Apr]; 71
(4
): 1349-57
PMID24496655
show ga
PURPOSE: To accelerate spectroscopic imaging using sparse sampling of (k,t)-space
and subspace (or low-rank) modeling to enable high-resolution metabolic imaging
with good signal-to-noise ratio. METHODS: The proposed method, called
SPectroscopic Imaging by exploiting spatiospectral CorrElation, exploits a unique
property known as partial separability of spectroscopic signals. This property
indicates that high-dimensional spectroscopic signals reside in a very
low-dimensional subspace and enables special data acquisition and image
reconstruction strategies to be used to obtain high-resolution spatiospectral
distributions with good signal-to-noise ratio. More specifically, a hybrid
chemical shift imaging/echo-planar spectroscopic imaging pulse sequence is
proposed for sparse sampling of (k,t)-space, and a low-rank model-based algorithm
is proposed for subspace estimation and image reconstruction from sparse data
with the capability to incorporate prior information and field inhomogeneity
correction. RESULTS: The performance of the proposed method has been evaluated
using both computer simulations and phantom studies, which produced very
encouraging results. For two-dimensional spectroscopic imaging experiments on a
metabolite phantom, a factor of 10 acceleration was achieved with a minimal loss
in signal-to-noise ratio compared to the long chemical shift imaging experiments
and with a significant gain in signal-to-noise ratio compared to the accelerated
echo-planar spectroscopic imaging experiments. CONCLUSION: The proposed method,
SPectroscopic Imaging by exploiting spatiospectral CorrElation, is able to
significantly accelerate spectroscopic imaging experiments, making
high-resolution metabolic imaging possible.