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2015 ; 1
(ä): 5
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A review of optical coherence tomography angiography (OCTA)
#MMPMID27847598
de Carlo TE
; Romano A
; Waheed NK
; Duker JS
Int J Retina Vitreous
2015[]; 1
(ä): 5
PMID27847598
show ga
Optical coherence tomography angiography (OCTA) is a new, non-invasive imaging
technique that generates volumetric angiography images in a matter of seconds.
This is a nascent technology with a potential wide applicability for retinal
vascular disease. At present, level 1 evidence of the technology's clinical
applications doesn't exist. In this paper, we introduce the technology, review
the available English language publications regarding OCTA, and compare it with
the current angiographic gold standards, fluorescein angiography (FA) and
indocyanine green angiography (ICGA). Finally we summarize its potential
application to retinal vascular diseases. OCTA is quick and non-invasive, and
provides volumetric data with the clinical capability of specifically localizing
and delineating pathology along with the ability to show both structural and
blood flow information in tandem. Its current limitations include a relatively
small field of view, inability to show leakage, and proclivity for image artifact
due to patient movement/blinking. Published studies hint at OCTA's potential
efficacy in the evaluation of common ophthalmologic diseases such age related
macular degeneration (AMD), diabetic retinopathy, artery and vein occlusions, and
glaucoma. OCTA can detect changes in choroidal blood vessel flow and can
elucidate the presence of choroidal neovascularization (CNV) in a variety of
conditions but especially in AMD. It provides a highly detailed view of the
retinal vasculature, which allows for accurate delineation of the foveal
avascular zone (FAZ) in diabetic eyes and detection of subtle microvascular
abnormalities in diabetic and vascular occlusive eyes. Optic disc perfusion in
glaucomatous eyes is notable as well on OCTA. Further studies are needed to more
definitively determine OCTA's utility in the clinical setting and to establish if
this technology may offer a non-invasive option of visualizing the retinal
vasculature in detail.