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2015 ; 2015
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A rare cause of severe lactic acidosis
#MMPMID25911351
Saeed S
; Kuravi A
; Rowley M
; Saeed M
BMJ Case Rep
2015[Apr]; 2015
(ä): ä PMID25911351
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Sarcoidosis is a multisystem disease of unknown aetiology with a classic
histology of non-caseating granulomas. It most often occurs in those below the
age of 50?years, and has a female preponderance. The main targets, often
symptomless, are the lung and hilar lymph nodes, although liver involvement is
not uncommon. Hepatic sarcoidosis encompasses a broad spectrum of presentations,
from asymptomatic hepatic granulomas with slight liver function test derangement
to severe liver involvement with cholestasis, advanced liver cirrhosis or chronic
liver failure. Mortality due to acute liver failure is far less common than lung
and heart involvement. We describe a case of fulminant liver failure with
multiorgan failure presenting initially with chronic non-specific symptoms, in
addition to minimal abnormal investigations such as mild anaemia, neutrophil
leucocytosis and mild obstructive liver dysfunction. Presenting features included
confusion, hypotension, oliguria and rapidly deteriorating liver function with
severe lactic acidosis. Postmortem examination confirmed extensive systemic
sarcoidosis.