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10.1101/gad.256370.114 http://scihub22266oqcxt.onion/10.1101/gad.256370.114 C4403261!4403261 !25877921     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25877921 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dev 2015 ; 29 (8 ): 862-75 Nephropedia Template TP {{tp|p=25877921 |t=2015. A protein interaction map of the LSU processome |pdf=|usr=}}{{25877921 }} gab.com Text A protein interaction map of the LSU processome JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25877921 #FOAvip Maturation of the large ribosomal subunit (LSU) in eukaryotes is a complex and highly coordinated process that requires the concerted action of a large, dynamic, ribonucleoprotein complex, the LSU processome. While we know that >80 ribosome biogenesis factors are required throughout the course of LSU assembly, little is known about how these factors interact with each other within the LSU processome. To interrogate its organization and architecture, we took a systems biology approach and performed a semi-high-throughput, array-based, directed yeast two-hybrid assay. Assaying 4800 protein-protein interactions, we identified 232 high-confidence, binary-interacting protein pairs, representing a fourfold increase from current knowledge. The resulting LSU processome interactome map has enhanced our understanding of the organization and function of the biogenesis factors within the LSU processome, revealing both novel and previously identified subcomplexes and hub proteins, including Nop4. Twit Text FOAVip A protein interaction map of the LSU processome ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25877921 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25877921 #FOAvip English Wikipedia <ref>{{Cite pmid|25877921 }}</ref> A protein interaction map of the LSU processome #MMPMID25877921 McCann KL ; Charette JM ; Vincent NG ; Baserga SJ Genes Dev 2015[Apr]; 29 (8 ): 862-75 PMID25877921 show ga Maturation of the large ribosomal subunit (LSU) in eukaryotes is a complex and highly coordinated process that requires the concerted action of a large, dynamic, ribonucleoprotein complex, the LSU processome. While we know that >80 ribosome biogenesis factors are required throughout the course of LSU assembly, little is known about how these factors interact with each other within the LSU processome. To interrogate its organization and architecture, we took a systems biology approach and performed a semi-high-throughput, array-based, directed yeast two-hybrid assay. Assaying 4800 protein-protein interactions, we identified 232 high-confidence, binary-interacting protein pairs, representing a fourfold increase from current knowledge. The resulting LSU processome interactome map has enhanced our understanding of the organization and function of the biogenesis factors within the LSU processome, revealing both novel and previously identified subcomplexes and hub proteins, including Nop4. |*Protein Interaction Maps [MESH] |Reproducibility of Results [MESH] |Ribosomal Proteins/*genetics/*metabolism [MESH] |Saccharomyces cerevisiae Proteins/genetics/*metabolism [MESH] |Saccharomyces cerevisiae/*genetics/*metabolism [MESH]A protein interaction map of the LSU processome (epmc).pdf DeepDyve Pubget Overpricing