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Cilia
2016 ; 5
(?): 17
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English Wikipedia
A primer on the mouse basal body
#MMPMID27114821
Garcia G 3rd
; Reiter JF
Cilia
2016[]; 5
(?): 17
PMID27114821
show ga
The basal body is a highly organized structure essential for the formation of
cilia. Basal bodies dock to a cellular membrane through their distal appendages
(also known as transition fibers) and provide the foundation on which the
microtubules of the ciliary axoneme are built. Consequently, basal body position
and orientation dictates the position and orientation of its cilium. The heart of
the basal body is the mother centriole, the older of the two centrioles inherited
during mitosis and which is comprised of nine triplet microtubules arranged in a
cylinder. Like all ciliated organisms, mice possess basal bodies, and studies of
mouse basal body structure have made diverse important contributions to the
understanding of how basal body structure impacts the function of cilia. The
appendages and associated structures of mouse basal bodies can differ in their
architecture from those of other organisms, and even between murine cell types.
For example, basal bodies of immotile primary cilia are connected to daughter
centrioles, whereas those of motile multiciliated cells are not. The last few
years have seen the identification of many components of the basal body, and the
mouse will continue to be an extremely valuable system for genetically defining
their functions.
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