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2017 ; 91
(7
): 2551-2575
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A primer on systematic reviews in toxicology
#MMPMID28501917
Hoffmann S
; de Vries RBM
; Stephens ML
; Beck NB
; Dirven HAAM
; Fowle JR 3rd
; Goodman JE
; Hartung T
; Kimber I
; Lalu MM
; Thayer K
; Whaley P
; Wikoff D
; Tsaioun K
Arch Toxicol
2017[Jul]; 91
(7
): 2551-2575
PMID28501917
show ga
Systematic reviews, pioneered in the clinical field, provide a transparent,
methodologically rigorous and reproducible means of summarizing the available
evidence on a precisely framed research question. Having matured to a
well-established approach in many research fields, systematic reviews are
receiving increasing attention as a potential tool for answering toxicological
questions. In the larger framework of evidence-based toxicology, the advantages
and obstacles of, as well as the approaches for, adapting and adopting systematic
reviews to toxicology are still being explored. To provide the toxicology
community with a starting point for conducting or understanding systematic
reviews, we herein summarized available guidance documents from various fields of
application. We have elaborated on the systematic review process by breaking it
down into ten steps, starting with planning the project, framing the question,
and writing and publishing the protocol, and concluding with interpretation and
reporting. In addition, we have identified the specific methodological challenges
of toxicological questions and have summarized how these can be addressed.
Ultimately, this primer is intended to stimulate scientific discussions of the
identified issues to fuel the development of toxicology-specific methodology and
to encourage the application of systematic review methodology to toxicological
issues.
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