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2015 ; 108
(9
): 2103-13
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A primer on Bayesian inference for biophysical systems
#MMPMID25954869
Hines KE
Biophys J
2015[May]; 108
(9
): 2103-13
PMID25954869
show ga
Bayesian inference is a powerful statistical paradigm that has gained popularity
in many fields of science, but adoption has been somewhat slower in biophysics.
Here, I provide an accessible tutorial on the use of Bayesian methods by focusing
on example applications that will be familiar to biophysicists. I first discuss
the goals of Bayesian inference and show simple examples of posterior inference
using conjugate priors. I then describe Markov chain Monte Carlo sampling and, in
particular, discuss Gibbs sampling and Metropolis random walk algorithms with
reference to detailed examples. These Bayesian methods (with the aid of Markov
chain Monte Carlo sampling) provide a generalizable way of rigorously addressing
parameter inference and identifiability for arbitrarily complicated models.