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10.1093/nar/gkv149 http://scihub22266oqcxt.onion/10.1093/nar/gkv149 C4381062!4381062 !25735750     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25735750 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleic+Acids+Res 2015 ; 43 (6 ): 3068-78 Nephropedia Template TP {{tp|p=25735750 |t=2015. A positioned +1 nucleosome enhances promoter-proximal pausing |pdf=|usr=}}{{25735750 }} gab.com Text A positioned +1 nucleosome enhances promoter-proximal pausing JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=25735750 #FOAvip Chromatin distribution is not uniform along the human genome. In most genes there is a promoter-associated nucleosome free region (NFR) followed by an array of nucleosomes towards the gene body in which the first (+1) nucleosome is strongly positioned. The function of this characteristic chromatin distribution in transcription is not fully understood. Here we show in vivo that the +1 nucleosome plays a role in modulating RNA polymerase II (RNAPII) promoter-proximal pausing. When a +1 nucleosome is strongly positioned, elongating RNAPII has a tendency to stall at the promoter-proximal region, recruits more negative elongation factor (NELF) and produces less mRNA. The nucleosome-induced pause favors pre-mRNA quality control by promoting the addition of the cap to the nascent RNA. Moreover, the uncapped RNAs produced in the absence of a positioned nucleosome are degraded by the 5'-3' exonuclease XRN2. Interestingly, reducing the levels of the chromatin remodeler ISWI factor SNF2H decreases +1 nucleosome positioning and increases RNAPII pause release. This work demonstrates a function for +1 nucleosome in regulation of transcription elongation, pre-mRNA processing and gene expression. Twit Text FOAVip A positioned +1 nucleosome enhances promoter-proximal pausing ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=25735750 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25735750 #FOAvip English Wikipedia <ref>{{Cite pmid|25735750 }}</ref> A positioned +1 nucleosome enhances promoter-proximal pausing #MMPMID25735750 Jimeno-González S ; Ceballos-Chávez M ; Reyes JC Nucleic Acids Res 2015[Mar]; 43 (6 ): 3068-78 PMID25735750 show ga Chromatin distribution is not uniform along the human genome. In most genes there is a promoter-associated nucleosome free region (NFR) followed by an array of nucleosomes towards the gene body in which the first (+1) nucleosome is strongly positioned. The function of this characteristic chromatin distribution in transcription is not fully understood. Here we show in vivo that the +1 nucleosome plays a role in modulating RNA polymerase II (RNAPII) promoter-proximal pausing. When a +1 nucleosome is strongly positioned, elongating RNAPII has a tendency to stall at the promoter-proximal region, recruits more negative elongation factor (NELF) and produces less mRNA. The nucleosome-induced pause favors pre-mRNA quality control by promoting the addition of the cap to the nascent RNA. Moreover, the uncapped RNAs produced in the absence of a positioned nucleosome are degraded by the 5'-3' exonuclease XRN2. Interestingly, reducing the levels of the chromatin remodeler ISWI factor SNF2H decreases +1 nucleosome positioning and increases RNAPII pause release. This work demonstrates a function for +1 nucleosome in regulation of transcription elongation, pre-mRNA processing and gene expression. |*Promoter Regions, Genetic [MESH] |Adenosine Triphosphatases/metabolism [MESH] |Animals [MESH] |Chromatin Assembly and Disassembly [MESH] |Chromosomal Proteins, Non-Histone/metabolism [MESH] |Exoribonucleases/metabolism [MESH] |Genes, myc [MESH] |Genome, Human [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Mice [MESH] |Nucleosomes/*genetics/*metabolism [MESH] |RNA Caps/genetics/metabolism [MESH] |RNA Polymerase II/metabolism [MESH] |RNA, Messenger/genetics/metabolism [MESH]A positioned +1 nucleosome enhances promoter-proximal pausing (epmc).pdf DeepDyve Pubget Overpricing