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2014 ; 289
(49
): 33712-29
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A passion for parasites
#MMPMID25336639
Englund PT
J Biol Chem
2014[Dec]; 289
(49
): 33712-29
PMID25336639
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I knew nothing and had thought nothing about parasites until 1971. In fact, if
you had asked me before then, I might have commented that parasites were rather
disgusting. I had been at the Johns Hopkins School of Medicine for three years,
and I was on the lookout for a new project. In 1971, I came across a paper in the
Journal of Molecular Biology by Larry Simpson, a classmate of mine in graduate
school. Larry's paper described a remarkable DNA structure known as kinetoplast
DNA (kDNA), isolated from a parasite. kDNA, the mitochondrial genome of
trypanosomatids, is a DNA network composed of several thousand interlocked DNA
rings. Almost nothing was known about it. I was looking for a project on DNA
replication, and I wanted it to be both challenging and important. I had no doubt
that working with kDNA would be a challenge, as I would be exploring uncharted
territory. I was also sure that the project would be important when I learned
that parasites with kDNA threaten huge populations in underdeveloped tropical
countries. Looking again at Larry's paper, I found the electron micrographs of
the kDNA networks to be rather beautiful. I decided to take a chance on kDNA.
Little did I know then that I would devote the next forty years of my life to
studying kDNA replication.
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