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2000 ; 91
(11
): 1096-9
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English Wikipedia
A novel "Nihon" rat model of a Mendelian dominantly inherited renal cell
carcinoma
#MMPMID11092972
Okimoto K
; Kouchi M
; Kikawa E
; Toyosawa K
; Koujitani T
; Tanaka K
; Matsuoka N
; Sakurai J
; Hino O
Jpn J Cancer Res
2000[Nov]; 91
(11
): 1096-9
PMID11092972
show ga
A novel rat model of hereditary renal cell carcinoma (RC) was found in a rat
colony of the Sprague-Dawley strain in Japan, and named the rising "Nihon" rat.
In this strain, RCs develop from early preneoplastic lesions, which begin to
appear at 4 weeks of age, forming adenomas by the age of 16 weeks. The RCs are
predominantly of clear cell type. Southern blot, northern blot and SSCP analyses
revealed no change in the Tsc1, Tsc2, VHL, and c-Met genes. Thus, the Nihon rat
should be a valuable experimental model for understanding renal carcinogenesis,
especially clear cell type, which is common among human RCs.