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2016 ; 68
(ä): 530-536
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A neural circuit encoding sexual preference in humans
#MMPMID27339689
Poeppl TB
; Langguth B
; Rupprecht R
; Laird AR
; Eickhoff SB
Neurosci Biobehav Rev
2016[Sep]; 68
(ä): 530-536
PMID27339689
show ga
Sexual preference determines mate choice for reproduction and hence guarantees
conservation of species in mammals. Despite this fundamental role in human
behavior, current knowledge on its target-specific neurofunctional substrate is
based on lesion studies and therefore limited. We used meta-analytic remodeling
of neuroimaging data from 364 human subjects with diverse sexual interests during
sexual stimulation to quantify neural regions associated with sexual preference
manipulations. We found that sexual preference is encoded by four
phylogenetically old, subcortical brain structures. More specifically, sexual
preference is controlled by the anterior and preoptic area of the hypothalamus,
the anterior and mediodorsal thalamus, the septal area, and the perirhinal
parahippocampus including the dentate gyrus. In contrast, sexual non-preference
is regulated by the substantia innominata. We anticipate the identification of a
core neural circuit for sexual preferences to be a starting point for further
sophisticated investigations into the neural principles of sexual behavior and
particularly of its aberrations.