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2017 ; 10
(2
): e1296614
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A network perspective on the virus world
#MMPMID28451057
Iranzo J
; Krupovic M
; Koonin EV
Commun Integr Biol
2017[]; 10
(2
): e1296614
PMID28451057
show ga
Viral evolution is characterized by high rates of horizontal gene transfer and
fast sequence divergence. Furthermore, there are no universal genes shared by all
viruses. As a result, distant relationships among viruses are better represented
by a network than by a tree. Here we discuss 3 network representations of the
virus world with decreasing levels of complexity, from a multilayer network that
integrates sequence conservation and patterns of gene sharing to a classic genome
similarity network. As new tools for network analysis are developed, we expect
that novel insights into virus evolution will result from the study of more
complex representations of the virus world.