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2015 ; 17
(5
): 88
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A multilayered microfluidic blood vessel-like structure
#MMPMID26256481
Hasan A
; Paul A
; Memic A
; Khademhosseini A
Biomed Microdevices
2015[Oct]; 17
(5
): 88
PMID26256481
show ga
There is an immense need for tissue engineered blood vessels. However, current
tissue engineering approaches still lack the ability to build native blood
vessel-like perfusable structures with multi-layered vascular walls. This paper
demonstrated a new method to fabricate tri-layer biomimetic blood vessel-like
structures on a microfluidic platform using photocrosslinkable gelatin hydrogel.
The presented method enables fabrication of physiological blood vessel-like
structures with mono-, bi- or tri-layer vascular walls. The diameter of the
vessels, the total thickness of the vessel wall and the thickness of each
individual layer of the wall were independently controlled. The developed
fabrication process is a simple and rapid method, allowing the physical
fabrication of the vascular structure in minutes, and the formation of a vascular
endothelial cell layer inside the vessels in 3-5 days. The fabricated vascular
constructs can potentially be used in numerous applications including drug
screening, development of in vitro models for cardiovascular diseases and/or
cancer metastasis, and study of vascular biology and mechanobiology.
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