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2017 ; 8
(ä): 15089
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A mouse tissue transcription factor atlas
#MMPMID28429721
Zhou Q
; Liu M
; Xia X
; Gong T
; Feng J
; Liu W
; Liu Y
; Zhen B
; Wang Y
; Ding C
; Qin J
Nat Commun
2017[Apr]; 8
(ä): 15089
PMID28429721
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Transcription factors (TFs) drive various biological processes ranging from
embryonic development to carcinogenesis. Here, we employ a recently developed
concatenated tandem array of consensus TF response elements (catTFRE) approach to
profile the activated TFs in 24 adult and 8 fetal mouse tissues on proteome
scale. A total of 941 TFs are quantitatively identified, representing over 60% of
the TFs in the mouse genome. Using an integrated omics approach, we present a TF
network in the major organs of the mouse, allowing data mining and generating
knowledge to elucidate the roles of TFs in various biological processes,
including tissue type maintenance and determining the general features of a
physiological system. This study provides a landscape of TFs in mouse tissues
that can be used to elucidate transcriptional regulatory specificity and
programming and as a baseline that may facilitate understanding diseases that are
regulated by TFs.
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