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2018 ; 293
(15
): 5386-5395
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A molecular perspective of mammalian autophagosome biogenesis
#MMPMID29371398
Mercer TJ
; Gubas A
; Tooze SA
J Biol Chem
2018[Apr]; 293
(15
): 5386-5395
PMID29371398
show ga
Autophagy is a highly conserved process and is essential for the maintenance of
cellular homeostasis. Autophagy occurs at a basal level in all cells, but it can
be up-regulated during stress, starvation, or infection. Misregulation of
autophagy has been linked to various disorders, including cancer,
neurodegeneration, and immune diseases. Here, we discuss the essential proteins
acting in the formation of an autophagosome, with a focus on the ULK and VPS34
kinase complexes, phosphatidylinositol 3-phosphate effector proteins, and the
transmembrane autophagy-related protein ATG9. The function and regulation of
these and other autophagy-related proteins acting during formation will be
addressed, in particular during amino acid starvation.