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Gut
2017 ; 66
(5
): 813-822
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A microbial signature for Crohn s disease
#MMPMID28179361
Pascal V
; Pozuelo M
; Borruel N
; Casellas F
; Campos D
; Santiago A
; Martinez X
; Varela E
; Sarrabayrouse G
; Machiels K
; Vermeire S
; Sokol H
; Guarner F
; Manichanh C
Gut
2017[May]; 66
(5
): 813-822
PMID28179361
show ga
OBJECTIVE: A decade of microbiome studies has linked IBD to an alteration in the
gut microbial community of genetically predisposed subjects. However, existing
profiles of gut microbiome dysbiosis in adult IBD patients are inconsistent among
published studies, and did not allow the identification of microbial signatures
for CD and UC. Here, we aimed to compare the faecal microbiome of CD with
patients having UC and with non-IBD subjects in a longitudinal study. DESIGN: We
analysed a cohort of 2045 non-IBD and IBD faecal samples from four countries
(Spain, Belgium, the UK and Germany), applied a 16S rRNA sequencing approach and
analysed a total dataset of 115 million sequences. RESULTS: In the Spanish
cohort, dysbiosis was found significantly greater in patients with CD than with
UC, as shown by a more reduced diversity, a less stable microbial community and
eight microbial groups were proposed as a specific microbial signature for CD.
Tested against the whole cohort, the signature achieved an overall sensitivity of
80% and a specificity of 94%, 94%, 89% and 91% for the detection of CD versus
healthy controls, patients with anorexia, IBS and UC, respectively. CONCLUSIONS:
Although UC and CD share many epidemiologic, immunologic, therapeutic and
clinical features, our results showed that they are two distinct subtypes of IBD
at the microbiome level. For the first time, we are proposing microbiomarkers to
discriminate between CD and non-CD independently of geographical regions.
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