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10.1038/srep26570 http://scihub22266oqcxt.onion/10.1038/srep26570 C4882593!4882593 !27231233     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27231233 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27231233 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 26570 Nephropedia Template TP {{tp|p=27231233 |t=2016. A melanosomal two-pore sodium channel regulates pigmentation |pdf=|usr=}}{{27231233 }} gab.com Text A melanosomal two-pore sodium channel regulates pigmentation JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27231233 #FOAvip Intracellular organelles mediate complex cellular functions that often require ion transport across their membranes. Melanosomes are organelles responsible for the synthesis of the major mammalian pigment melanin. Defects in melanin synthesis result in pigmentation defects, visual deficits, and increased susceptibility to skin and eye cancers. Although genes encoding putative melanosomal ion transporters have been identified as key regulators of melanin synthesis, melanosome ion transport and its contribution to pigmentation remain poorly understood. Here we identify two-pore channel 2 (TPC2) as the first reported melanosomal cation conductance by directly patch-clamping skin and eye melanosomes. TPC2 has been implicated in human pigmentation and melanoma, but the molecular mechanism mediating this function was entirely unknown. We demonstrate that the vesicular signaling lipid phosphatidylinositol bisphosphate PI(3,5)P2 modulates TPC2 activity to control melanosomal membrane potential, pH, and regulate pigmentation. Twit Text FOAVip A melanosomal two-pore sodium channel regulates pigmentation ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27231233 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27231233 #FOAvip English Wikipedia <ref>{{Cite pmid|27231233 }}</ref> A melanosomal two-pore sodium channel regulates pigmentation #MMPMID27231233 Bellono NW ; Escobar IE ; Oancea E Sci Rep 2016[May]; 6 (ä): 26570 PMID27231233 show ga Intracellular organelles mediate complex cellular functions that often require ion transport across their membranes. Melanosomes are organelles responsible for the synthesis of the major mammalian pigment melanin. Defects in melanin synthesis result in pigmentation defects, visual deficits, and increased susceptibility to skin and eye cancers. Although genes encoding putative melanosomal ion transporters have been identified as key regulators of melanin synthesis, melanosome ion transport and its contribution to pigmentation remain poorly understood. Here we identify two-pore channel 2 (TPC2) as the first reported melanosomal cation conductance by directly patch-clamping skin and eye melanosomes. TPC2 has been implicated in human pigmentation and melanoma, but the molecular mechanism mediating this function was entirely unknown. We demonstrate that the vesicular signaling lipid phosphatidylinositol bisphosphate PI(3,5)P2 modulates TPC2 activity to control melanosomal membrane potential, pH, and regulate pigmentation. |*Pigmentation [MESH] |Animals [MESH] |Calcium Channels/genetics/*metabolism [MESH] |Cells, Cultured [MESH] |Eye/*cytology/metabolism [MESH] |Hydrogen-Ion Concentration [MESH] |Melanocytes/cytology/metabolism [MESH] |Melanosomes/*metabolism/physiology [MESH] |Membrane Potentials [MESH] |Mice [MESH] |Patch-Clamp Techniques [MESH] |Phosphatidylinositol 4,5-Diphosphate/metabolism [MESH]A melanosomal two-pore sodium channel regulates pigmentation (epmc).pdf DeepDyve Pubget Overpricing