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2016 ; 126
(9
): 3185-7
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A hidden residential cell in the lung
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Rothenberg ME
J Clin Invest
2016[Sep]; 126
(9
): 3185-7
PMID27548525
show ga
Eosinophils are classically known as proinflammatory cells, as they are equipped
with a variety of preformed cytotoxic mediators and have been shown to
definitively contribute to asthma. The connection between eosinophils and asthma
development has led to a new class of asthma therapeutics based on blocking
eosinophils with humanized antibodies that neutralize IL-5, a potent eosinophil
growth, activation, and survival factor. Yet, recent studies have led to an
increasing appreciation that eosinophils have a variety of homeostatic functions,
including immunomodulation. In this issue of the JCI, Mesnil et al. identify a
notable population of lung-resident eosinophils and demonstrate that, compared
with traditional eosinophils, these cells have distinct characteristics,
including nuclear structure, surface markers, IL-5 independence, and
immunoregulatory function that is capable of polarizing adaptive immune
responses, at least in vitro. Thus, these results reinforce a key homeostatic
role for this enigmatic cell population, particularly in residing and regulating
immunity in the lung.
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