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2016 ; 16
(9
): 553-65
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A guide to immunometabolism for immunologists
#MMPMID27396447
O'Neill LA
; Kishton RJ
; Rathmell J
Nat Rev Immunol
2016[Sep]; 16
(9
): 553-65
PMID27396447
show ga
In recent years a substantial number of findings have been made in the area of
immunometabolism, by which we mean the changes in intracellular metabolic
pathways in immune cells that alter their function. Here, we provide a brief
refresher course on six of the major metabolic pathways involved (specifically,
glycolysis, the tricarboxylic acid (TCA) cycle, the pentose phosphate pathway,
fatty acid oxidation, fatty acid synthesis and amino acid metabolism), giving
specific examples of how precise changes in the metabolites of these pathways
shape the immune cell response. What is emerging is a complex interplay between
metabolic reprogramming and immunity, which is providing an extra dimension to
our understanding of the immune system in health and disease.