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10.1182/blood-2016-01-678151 http://scihub22266oqcxt.onion/10.1182/blood-2016-01-678151 C4882802!4882802 !27053532     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27053532 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood 2016 ; 127 (21 ): 2525-35 Nephropedia Template TP {{tp|p=27053532 |t=2016. A genome editing primer for the hematologist |pdf=|usr=}}{{27053532 }} gab.com Text A genome editing primer for the hematologist JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=27053532 #FOAvip Gene editing enables the site-specific modification of the genome. These technologies have rapidly advanced such that they have entered common use in experimental hematology to investigate genetic function. In addition, genome editing is becoming increasingly plausible as a treatment modality to rectify genetic blood disorders and improve cellular therapies. Genome modification typically ensues from site-specific double-strand breaks and may result in a myriad of outcomes. Even single-strand nicks and targeted biochemical modifications that do not permanently alter the DNA sequence (epigenome editing) may be powerful instruments. In this review, we examine the various technologies, describe their advantages and shortcomings for engendering useful genetic alterations, and consider future prospects for genome editing to impact hematology. Twit Text FOAVip A genome editing primer for the hematologist ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=27053532 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27053532 #FOAvip English Wikipedia <ref>{{Cite pmid|27053532 }}</ref> A genome editing primer for the hematologist #MMPMID27053532 Hoban MD ; Bauer DE Blood 2016[May]; 127 (21 ): 2525-35 PMID27053532 show ga Gene editing enables the site-specific modification of the genome. These technologies have rapidly advanced such that they have entered common use in experimental hematology to investigate genetic function. In addition, genome editing is becoming increasingly plausible as a treatment modality to rectify genetic blood disorders and improve cellular therapies. Genome modification typically ensues from site-specific double-strand breaks and may result in a myriad of outcomes. Even single-strand nicks and targeted biochemical modifications that do not permanently alter the DNA sequence (epigenome editing) may be powerful instruments. In this review, we examine the various technologies, describe their advantages and shortcomings for engendering useful genetic alterations, and consider future prospects for genome editing to impact hematology. |Animals [MESH] |Gene Editing/*methods [MESH] |Hematologic Diseases/*genetics/*therapy [MESH] |Humans [MESH]A genome editing primer for the hematologist (epmc).pdf DeepDyve Pubget Overpricing