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2017 ; 9
(6
): 1725-1729
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A general introduction to adjustment for multiple comparisons
#MMPMID28740688
Chen SY
; Feng Z
; Yi X
J Thorac Dis
2017[Jun]; 9
(6
): 1725-1729
PMID28740688
show ga
In experimental research a scientific conclusion is always drawn from the
statistical testing of hypothesis, in which an acceptable cutoff of probability,
such as 0.05 or 0.01, is used for decision-making. However, the probability of
committing false statistical inferences would considerably increase when more
than one hypothesis is simultaneously tested (namely the multiple comparisons),
which therefore requires proper adjustment. Although the adjustment for multiple
comparisons is proposed to be mandatory in some journals, it still remains
difficult to select a proper method suitable for the various experimental
properties and study purposes, especially for researchers without good background
in statistics. In the present paper, we provide a brief review on mathematical
framework, general concepts and common methods of adjustment for multiple
comparisons, which is expected to facilitate the understanding and selection of
adjustment methods.