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2015 ; 6
(ä): 171
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A comprehensive review of amyotrophic lateral sclerosis
#MMPMID26629397
Zarei S
; Carr K
; Reiley L
; Diaz K
; Guerra O
; Altamirano PF
; Pagani W
; Lodin D
; Orozco G
; Chinea A
Surg Neurol Int
2015[]; 6
(ä): 171
PMID26629397
show ga
Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative
disease affecting motor neurons with an incidence of about 1/100,000. Most ALS
cases are sporadic, but 5-10% of the cases are familial ALS. Both sporadic and
familial ALS (FALS) are associated with degeneration of cortical and spinal motor
neurons. The etiology of ALS remains unknown. However, mutations of superoxide
dismutase 1 have been known as the most common cause of FALS. In this study, we
provide a comprehensive review of ALS. We cover all aspects of the disease
including epidemiology, comorbidities, environmental risk factor, molecular
mechanism, genetic factors, symptoms, diagnostic, treatment, and even the
available supplement and management of ALS. This will provide the reader with an
advantage of receiving a broad range of information about the disease.