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10.1093/nar/gkw1067 http://scihub22266oqcxt.onion/10.1093/nar/gkw1067 C5389711!5389711!27899577     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27899577.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleic+Acids+Res 2017 ; 45 (5): e31 Nephropedia Template TP {{tp|p=27899577|t=2017. A comprehensive approach to expression of L1 loci |pdf=|usr=}}{{27899577}} gab.com Text A comprehensive approach to expression of L1 loci JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=27899577 #FOAvip L1 elements represent the only currently active, autonomous retrotransposon in the human genome, and they make major contributions to human genetic instability. The vast majority of the 500 000 L1 elements in the genome are defective, and only a relatively few can contribute to the retrotransposition process. However, there is currently no comprehensive approach to identify the specific loci that are actively transcribed separate from the excess of L1-related sequences that are co-transcribed within genes. We have developed RNA-Seq procedures, as well as a 1200 bp 5? RACE product coupled with PACBio sequencing that can identify the specific L1 loci that contribute most of the L1-related RNA reads. At least 99% of L1-related sequences found in RNA do not arise from the L1 promoter, instead representing pieces of L1 incorporated in other cellular RNAs. In any given cell type a relatively few active L1 loci contribute to the ?authentic? L1 transcripts that arise from the L1 promoter, with significantly different loci seen expressed in different tissues. Twit Text FOAVip A comprehensive approach to expression of L1 loci ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=27899577 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27899577 #FOAvip English Wikipedia <ref>{{Cite pmid|27899577}}</ref> A comprehensive approach to expression of L1 loci #MMPMID27899577 Deininger P; Morales ME; White TB; Baddoo M; Hedges DJ; Servant G; Srivastav S; Smither ME; Concha M; DeHaro DL; Flemington EK; Belancio VP Nucleic Acids Res 2017[Mar]; 45 (5): e31 PMID27899577show ga L1 elements represent the only currently active, autonomous retrotransposon in the human genome, and they make major contributions to human genetic instability. The vast majority of the 500 000 L1 elements in the genome are defective, and only a relatively few can contribute to the retrotransposition process. However, there is currently no comprehensive approach to identify the specific loci that are actively transcribed separate from the excess of L1-related sequences that are co-transcribed within genes. We have developed RNA-Seq procedures, as well as a 1200 bp 5? RACE product coupled with PACBio sequencing that can identify the specific L1 loci that contribute most of the L1-related RNA reads. At least 99% of L1-related sequences found in RNA do not arise from the L1 promoter, instead representing pieces of L1 incorporated in other cellular RNAs. In any given cell type a relatively few active L1 loci contribute to the ?authentic? L1 transcripts that arise from the L1 promoter, with significantly different loci seen expressed in different tissues. äA comprehensive approach to expression of L1 loci (epmc).pdf DeepDyve Pubget Overpricing