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10.1016/j.clim.2014.10.004 http://scihub22266oqcxt.onion/10.1016/j.clim.2014.10.004 C4602403!4602403 !25451161     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25451161 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25451161 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Immunol 2015 ; 156 (1 ): 1-8 Nephropedia Template TP {{tp|p=25451161 |t=2015. A chimeric human-mouse model of Sjögren s syndrome |pdf=|usr=}}{{25451161 }} gab.com Text A chimeric human-mouse model of Sjögren s syndrome JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25451161 #FOAvip Despite recent advances in the understanding of Sjögren's Syndrome (SjS), the pathogenic mechanisms remain elusive and an ideal model for early drug discovery is not yet available. To establish a humanized mouse model of SjS, peripheral blood mononuclear cells (PBMCs) from healthy volunteers or patients with SjS were transferred into immunodeficient NOD-scid IL-2r?(null) mouse recipients to produce chimeric mice. While no difference was observed in the distribution of cells, chimeric mice transferred with PBMCs from SjS patients produced enhanced cytokine levels, most significantly IFN-? and IL-10. Histological examination revealed enhanced inflammatory responses in the lacrimal and salivary glands of SjS chimeras, as measured by digital image analysis and blinded histopathological scoring. Infiltrates were primarily CD4+, with minimal detection of CD8+ T-cells and B-cells. These results demonstrate a novel chimeric mouse model of human SjS that provides a unique in vivo environment to test experimental therapeutics and investigate T-cell disease pathology. Twit Text FOAVip A chimeric human-mouse model of Sjögren s syndrome ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25451161 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25451161 #FOAvip English Wikipedia <ref>{{Cite pmid|25451161 }}</ref> A chimeric human-mouse model of Sjögren s syndrome #MMPMID25451161 Young NA ; Wu LC ; Bruss M ; Kaffenberger BH ; Hampton J ; Bolon B ; Jarjour WN Clin Immunol 2015[Jan]; 156 (1 ): 1-8 PMID25451161 show ga Despite recent advances in the understanding of Sjögren's Syndrome (SjS), the pathogenic mechanisms remain elusive and an ideal model for early drug discovery is not yet available. To establish a humanized mouse model of SjS, peripheral blood mononuclear cells (PBMCs) from healthy volunteers or patients with SjS were transferred into immunodeficient NOD-scid IL-2r?(null) mouse recipients to produce chimeric mice. While no difference was observed in the distribution of cells, chimeric mice transferred with PBMCs from SjS patients produced enhanced cytokine levels, most significantly IFN-? and IL-10. Histological examination revealed enhanced inflammatory responses in the lacrimal and salivary glands of SjS chimeras, as measured by digital image analysis and blinded histopathological scoring. Infiltrates were primarily CD4+, with minimal detection of CD8+ T-cells and B-cells. These results demonstrate a novel chimeric mouse model of human SjS that provides a unique in vivo environment to test experimental therapeutics and investigate T-cell disease pathology. |*Chimera [MESH] |*Disease Models, Animal [MESH] |*Sjogren's Syndrome/immunology [MESH] |Animals [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Flow Cytometry [MESH] |Humans [MESH]A chimeric human-mouse model of Sjögren s syndrome (epmc).pdf DeepDyve Pubget Overpricing