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2012 ; 1
(2
): 77-81
Nephropedia Template TP
gab.com Text
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English Wikipedia
A case of the "cellular variant" of focal segmental glomerulosclerosis with acute
renal failure that remitted completely with oral steroid administration
#MMPMID28509069
Konno G
; Someya G
; Sekine K
; Nishino T
; Kawamoto S
CEN Case Rep
2012[Nov]; 1
(2
): 77-81
PMID28509069
show ga
A 73-year-old man with systemic edema and oliguria, which appeared within several
days, was referred to our hospital. Urinalysis showed massive proteinuria, and
the blood examination results indicated nephrotic syndrome. Renal biopsy revealed
the existence of focal segmental glomerulosclerosis (FSGS), and further
investigation indicated that the microscopic features were consistent with the
"cellular variant (CELL)" according to the Columbia Classification. After biopsy,
40 mg per day of oral prednisolone was administered daily. With steroid therapy,
the abnormal values of the blood examination and urinalysis gradually reached
normal, and complete remission was achieved on day 43 after initiating steroid
administration. Microscopic investigation by follow-up renal re-biopsy revealed
several sclerosing glomeruli; however, other intact glomeruli had no endothelial
proliferation, which is a hallmark of CELL. The patient was discharged after
biopsy and observed as an outpatient, with maintenance of clinical remission.