Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23472635
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 ACS+Chem+Neurosci
2013 ; 4
(6
): 909-17
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
A calcium-relay mechanism in vertebrate phototransduction
#MMPMID23472635
Koch KW
; Dell'orco D
ACS Chem Neurosci
2013[Jun]; 4
(6
): 909-17
PMID23472635
show ga
Calcium-signaling in cells requires a fine-tuned system of calcium-transport
proteins involving ion channels, exchangers, and ion-pumps but also
calcium-sensor proteins and their targets. Thus, control of physiological
responses very often depends on incremental changes of the cytoplasmic calcium
concentration, which are sensed by calcium-binding proteins and are further
transmitted to specific target proteins. This Review will focus on
calcium-signaling in vertebrate photoreceptor cells, where recent physiological
and biochemical data indicate that a subset of neuronal calcium sensor proteins
named guanylate cyclase-activating proteins (GCAPs) operate in a calcium-relay
system, namely, to make gradual responses to small changes in calcium. We will
further integrate this mechanism in an existing computational model of
phototransduction showing that it is consistent and compatible with the dynamics
that are characteristic for the precise operation of the phototransduction
pathways.
free
free
free
