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2016 ; 38
(2
): 213-20
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A bug s life in the granuloma
#MMPMID26577238
Martin CJ
; Carey AF
; Fortune SM
Semin Immunopathol
2016[Mar]; 38
(2
): 213-20
PMID26577238
show ga
The granuloma is the defining feature of the host response to infection with
Mycobacterium tuberculosis (Mtb). Despite knowing of its existence for centuries,
much remains unclear regarding the host and bacterial factors that contribute to
granuloma formation, heterogeneity of presentation, and the forces at play
within. Mtb is highly adapted to life within the granuloma and employs many
unique strategies to both create a niche within the host as well as survive the
stresses imposed upon it. Adding to the complexity of the granuloma is the vast
range of pathology observed, often within the same individual. Here, we explore
some of the many ways in which Mtb crafts the immune response to its liking and
builds a variety of granuloma features that contribute to its survival. We also
consider the multitude of ways that Mtb is adapted to life in the granuloma and
how variability in the deployment of these strategies may result in different
fates for both the bacterium and the host. It is through better understanding of
these complex interactions that we may begin to strategize novel approaches for
tuberculosis treatments.
|*Host-Pathogen Interactions/immunology
[MESH]
|Adaptation, Biological
[MESH]
|Animals
[MESH]
|Antigens, Bacterial/immunology
[MESH]
|Antitubercular Agents/pharmacology/therapeutic use
[MESH]
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