Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28955846
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biochem+Biophys+Rep
2016 ; 5
(ä): 388-395
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
A bouquet of DNA structures: Emerging diversity
#MMPMID28955846
Kaushik M
; Kaushik S
; Roy K
; Singh A
; Mahendru S
; Kumar M
; Chaudhary S
; Ahmed S
; Kukreti S
Biochem Biophys Rep
2016[Mar]; 5
(ä): 388-395
PMID28955846
show ga
Structural polymorphism of DNA has constantly been evolving from the time of
illustration of the double helical model of DNA by Watson and Crick. A variety of
non-canonical DNA structures have constantly been documented across the globe.
DNA attracted worldwide attention as a carrier of genetic information. In
addition to the classical Watson-Crick duplex, DNA can actually adopt diverse
structures during its active participation in cellular processes like
replication, transcription, recombination and repair. Structures like hairpin,
cruciform, triplex, G-triplex, quadruplex, i-motif and other alternative
non-canonical DNA structures have been studied at length and have also shown
their in vivo occurrence. This review mainly focuses on non-canonical structures
adopted by DNA oligonucleotides which have certain prerequisites for their
formation in terms of sequence, its length, number and orientation of strands
along with varied solution conditions. This conformational polymorphism of DNA
might be the basis of different functional properties of a specific set of DNA
sequences, further giving some insights for various extremely complicated
biological phenomena. Many of these structures have already shown their linkages
with diseases like cancer and genetic disorders, hence making them an extremely
striking target for structure-specific drug designing and therapeutic
applications.
free
free
free
