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10.1016/j.cell.2017.08.026 http://scihub22266oqcxt.onion/10.1016/j.cell.2017.08.026 C5610190!5610190 !28938116     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28938116 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell 2017 ; 171 (1 ): 242-255.e27 Nephropedia Template TP {{tp|p=28938116 |t=2017. A Unifying Theory of Branching Morphogenesis |pdf=|usr=}}{{28938116 }} gab.com Text A Unifying Theory of Branching Morphogenesis JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=28938116 #FOAvip The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear how macroscopic features of branched organs, including their size, network topology, and spatial patterning, are encoded. Here, we show that, in mouse mammary gland, kidney, and human prostate, these features can be explained quantitatively within a single unifying framework of branching and annihilating random walks. Based on quantitative analyses of large-scale organ reconstructions and proliferation kinetics measurements, we propose that morphogenesis follows from the proliferative activity of equipotent tips that stochastically branch and randomly explore their environment but compete neutrally for space, becoming proliferatively inactive when in proximity with neighboring ducts. These results show that complex branched epithelial structures develop as a self-organized process, reliant upon a strikingly simple but generic rule, without recourse to a rigid and deterministic sequence of genetically programmed events. Twit Text FOAVip A Unifying Theory of Branching Morphogenesis ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=28938116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28938116 #FOAvip English Wikipedia <ref>{{Cite pmid|28938116 }}</ref> A Unifying Theory of Branching Morphogenesis #MMPMID28938116 Hannezo E ; Scheele CLGJ ; Moad M ; Drogo N ; Heer R ; Sampogna RV ; van Rheenen J ; Simons BD Cell 2017[Sep]; 171 (1 ): 242-255.e27 PMID28938116 show ga The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear how macroscopic features of branched organs, including their size, network topology, and spatial patterning, are encoded. Here, we show that, in mouse mammary gland, kidney, and human prostate, these features can be explained quantitatively within a single unifying framework of branching and annihilating random walks. Based on quantitative analyses of large-scale organ reconstructions and proliferation kinetics measurements, we propose that morphogenesis follows from the proliferative activity of equipotent tips that stochastically branch and randomly explore their environment but compete neutrally for space, becoming proliferatively inactive when in proximity with neighboring ducts. These results show that complex branched epithelial structures develop as a self-organized process, reliant upon a strikingly simple but generic rule, without recourse to a rigid and deterministic sequence of genetically programmed events. |*Models, Biological [MESH] |*Morphogenesis [MESH] |Animals [MESH] |Female [MESH] |Humans [MESH] |Kidney/embryology/*growth & development [MESH] |Male [MESH] |Mammary Glands, Human/embryology/*growth & development [MESH] |Mice [MESH]A Unifying Theory of Branching Morphogenesis (epmc).pdf DeepDyve Pubget Overpricing