Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23511028
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23511028
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Channels+(Austin)
2013 ; 7
(3
): 211-4
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
A TRP to cardiac fibroblast differentiation
#MMPMID23511028
Thodeti CK
; Paruchuri S
; Meszaros JG
Channels (Austin)
2013[May]; 7
(3
): 211-4
PMID23511028
show ga
The differentiation of cardiac fibroblasts to myofibroblasts is one of the key
events during cardiac remodeling, however, the molecular mechanism underlying
this process is not well known. Calcium signaling plays an important role in the
regulation of cardiac fibroblast function, but its role in the differentiation of
fibroblasts is undefined. Recently four Transient Receptor Potential (TRP)
channels TRPM7, TRPC3, TRPC6 and TRPV4 were shown to be crucial for the
differentiation of cardiac fibroblasts to myofibroblasts. This addendum sums up
the roles described for these four TRP channels in cardiac fibroblast
differentiation, and discusses the possible molecular mechanisms underlying this
process and its relevance for cardiac remodeling in disease.