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2016 ; 7
(ä): 184
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A T Cell View of the Bone Marrow
#MMPMID27242791
Bonomo A
; Monteiro AC
; Gonçalves-Silva T
; Cordeiro-Spinetti E
; Galvani RG
; Balduino A
Front Immunol
2016[]; 7
(ä): 184
PMID27242791
show ga
The majority of T cells present in the bone marrow (BM) represent an
activated/memory phenotype and most of these, if not all, are circulating T
cells. Their lodging in the BM keeps them activated, turning the BM
microenvironment into a "memory reservoir." This article will focus on how T cell
activation in the BM results in both direct and indirect effects on the
hematopoiesis. The hematopoietic stem cell niche will be presented, with its main
components and organization, along with the role played by T lymphocytes in basal
and pathologic conditions and their effect on the bone remodeling process. Also
discussed herein will be how "normal" bone mass peak is achieved only in the
presence of an intact adaptive immune system, with T and B cells playing critical
roles in this process. Our main hypothesis is that the partnership between T
cells and cells of the BM microenvironment orchestrates numerous processes
regulating immunity, hematopoiesis, and bone remodeling.