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10.3389/fimmu.2016.00184

http://scihub22266oqcxt.onion/10.3389/fimmu.2016.00184
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suck abstract from ncbi


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pmid27242791
      Front+Immunol 2016 ; 7 (ä): 184
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  • A T Cell View of the Bone Marrow #MMPMID27242791
  • Bonomo A ; Monteiro AC ; Gonçalves-Silva T ; Cordeiro-Spinetti E ; Galvani RG ; Balduino A
  • Front Immunol 2016[]; 7 (ä): 184 PMID27242791 show ga
  • The majority of T cells present in the bone marrow (BM) represent an activated/memory phenotype and most of these, if not all, are circulating T cells. Their lodging in the BM keeps them activated, turning the BM microenvironment into a "memory reservoir." This article will focus on how T cell activation in the BM results in both direct and indirect effects on the hematopoiesis. The hematopoietic stem cell niche will be presented, with its main components and organization, along with the role played by T lymphocytes in basal and pathologic conditions and their effect on the bone remodeling process. Also discussed herein will be how "normal" bone mass peak is achieved only in the presence of an intact adaptive immune system, with T and B cells playing critical roles in this process. Our main hypothesis is that the partnership between T cells and cells of the BM microenvironment orchestrates numerous processes regulating immunity, hematopoiesis, and bone remodeling.
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