Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1093/gbe/evae103 http://scihub22266oqcxt.onion/10.1093/gbe/evae103 38748819!11152449!38748819     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genome+Biol+Evol 2024 ; 16 (6): ä Nephropedia Template TP {{tp|p=38748819|t=2024. A Synergistic, Cultivator Model of De Novo Gene Origination |pdf=|usr=}}{{38748819}} gab.com Text A Synergistic, Cultivator Model of De Novo Gene Origination JO: Genome Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=38748819 #FOAvip The origin and fixation of evolutionarily young genes is a fundamental question in evolutionary biology. However, understanding the origins of newly evolved genes arising de novo from noncoding genomic sequences is challenging. This is partly due to the low likelihood that several neutral or nearly neutral mutations fix prior to the appearance of an important novel molecular function. This issue is particularly exacerbated in large effective population sizes where the effect of drift is small. To address this problem, we propose a regulation-focused, cultivator model for de novo gene evolution. This cultivator-focused model posits that each step in a novel variant's evolutionary trajectory is driven by well-defined, selectively advantageous functions for the cultivator genes, rather than solely by the de novo genes, emphasizing the critical role of genome organization in the evolution of new genes. Twit Text FOAVip A Synergistic, Cultivator Model of De Novo Gene Origination ????Genome Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=38748819 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=38748819 #FOAvip English Wikipedia <ref>{{Cite pmid|38748819}}</ref> A Synergistic, Cultivator Model of De Novo Gene Origination #MMPMID38748819 Lee U; Mozeika SM; Zhao L Genome Biol Evol 2024[Jun]; 16 (6): ä PMID38748819show ga The origin and fixation of evolutionarily young genes is a fundamental question in evolutionary biology. However, understanding the origins of newly evolved genes arising de novo from noncoding genomic sequences is challenging. This is partly due to the low likelihood that several neutral or nearly neutral mutations fix prior to the appearance of an important novel molecular function. This issue is particularly exacerbated in large effective population sizes where the effect of drift is small. To address this problem, we propose a regulation-focused, cultivator model for de novo gene evolution. This cultivator-focused model posits that each step in a novel variant's evolutionary trajectory is driven by well-defined, selectively advantageous functions for the cultivator genes, rather than solely by the de novo genes, emphasizing the critical role of genome organization in the evolution of new genes. |*Evolution, Molecular[MESH] |*Models, Genetic[MESH] |Humans[MESH] |Mutation[MESH]A Synergistic, Cultivator Model of De Novo Gene Origination (epmc).pdf DeepDyve Pubget Overpricing