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A Susceptible Mouse Model for Zika Virus Infection
#MMPMID27149521
Dowall SD
; Graham VA
; Rayner E
; Atkinson B
; Hall G
; Watson RJ
; Bosworth A
; Bonney LC
; Kitchen S
; Hewson R
PLoS Negl Trop Dis
2016[May]; 10
(5
): e0004658
PMID27149521
show ga
Zika virus (ZIKV) is a mosquito-borne pathogen which has recently spread beyond
Africa and into Pacific and South American regions. Despite first being detected
in 1947, very little information is known about the virus, and its spread has
been associated with increases in Guillain-Barre syndrome and microcephaly. There
are currently no known vaccines or antivirals against ZIKV infection. Progress in
assessing interventions will require the development of animal models to test
efficacies; however, there are only limited reports on in vivo studies. The only
susceptible murine models have involved intracerebral inoculations or juvenile
animals, which do not replicate natural infection. Our report has studied the
effect of ZIKV infection in type-I interferon receptor deficient (A129) mice and
the parent strain (129Sv/Ev) after subcutaneous challenge in the lower leg to
mimic a mosquito bite. A129 mice developed severe symptoms with widespread viral
RNA detection in the blood, brain, spleen, liver and ovaries. Histological
changes were also striking in these animals. 129Sv/Ev mice developed no clinical
symptoms or histological changes, despite viral RNA being detectable in the
blood, spleen and ovaries, albeit at lower levels than those seen in A129 mice.
Our results identify A129 mice as being highly susceptible to ZIKV and thus A129
mice represent a suitable, and urgently required, small animal model for the
testing of vaccines and antivirals.
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