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2017 ; 8
(ä): 550
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A Role for Neutrophils in Viral Respiratory Disease
#MMPMID28553293
Camp JV
; Jonsson CB
Front Immunol
2017[]; 8
(ä): 550
PMID28553293
show ga
Neutrophils are immune cells that are well known to be present during many types
of lung diseases associated with acute respiratory distress syndrome (ARDS) and
may contribute to acute lung injury. Neutrophils are poorly studied with respect
to viral infection, and specifically to respiratory viral disease. Influenza A
virus (IAV) infection is the cause of a respiratory disease that poses a
significant global public health concern. Influenza disease presents as a
relatively mild and self-limiting although highly pathogenic forms exist.
Neutrophils increase in the respiratory tract during infection with mild seasonal
IAV, moderate and severe epidemic IAV infection, and emerging highly pathogenic
avian influenza (HPAI). During severe influenza pneumonia and HPAI infection, the
number of neutrophils in the lower respiratory tract is correlated with disease
severity. Thus, comparative analyses of the relationship between IAV infection
and neutrophils provide insights into the relative contribution of host and viral
factors that contribute to disease severity. Herein, we review the contribution
of neutrophils to IAV disease pathogenesis and to other respiratory virus
infections.
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