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2016 ; 14
(ä): 8-15
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A Review on Genomics APIs
#MMPMID26702340
Swaminathan R
; Huang Y
; Moosavinasab S
; Buckley R
; Bartlett CW
; Lin SM
Comput Struct Biotechnol J
2016[]; 14
(ä): 8-15
PMID26702340
show ga
The constant improvement and falling prices of whole human genome Next Generation
Sequencing (NGS) has resulted in rapid adoption of genomic information at both
clinics and research institutions. Considered together, the complexity of
genomics data, due to its large volume and diversity along with the need for
genomic data sharing, has resulted in the creation of Application Programming
Interface (API) for secure, modular, interoperable access to genomic data from
different applications, platforms, and even organizations. The Genomics APIs are
a set of special protocols that assist software developers in dealing with
multiple genomic data sources for building seamless, interoperable applications
leading to the advancement of both genomic and clinical research. These APIs help
define a standard for retrieval of genomic data from multiple sources as well as
to better package genomic information for integration with Electronic Health
Records. This review covers three currently available Genomics APIs: a) Google
Genomics, b) SMART Genomics, and c) 23andMe. The functionalities, reference
implementations (if available) and authentication protocols of each API are
reviewed. A comparative analysis of the different features across the three APIs
is provided in the Discussion section. Though Genomics APIs are still under
active development and have yet to reach widespread adoption, they hold the
promise to make building of complicated genomics applications easier with
downstream constructive effects on healthcare.