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A Review of Clinical Translation of Inorganic Nanoparticles
#MMPMID25956384
Anselmo AC
; Mitragotri S
AAPS J
2015[Sep]; 17
(5
): 1041-54
PMID25956384
show ga
Inorganic nanoparticles are widely used for therapeutic and diagnostic purposes
as they offer unique features as compared with their organic and polymeric
counterparts. As such, inorganic nanoparticles represent an exciting opportunity
to develop drug delivery and imaging systems that are poised to tackle unique
challenges which are currently unaddressed in clinical settings. Despite these
clear advantages, very few inorganic nanoparticle systems have entered the
clinic. Here, we review the current clinical landscape of inorganic nanoparticle
systems and their opportunities and challenges, with particular emphasis on
gold-, iron-oxide- and silica-based nanoparticle systems. Key examples of
inorganic nanoparticles that are currently being investigated in the clinic
(e.g., trials which are recruiting or currently active but not completed) are
highlighted, along with the preclinical work that these examples have leveraged
to transition from the lab to the clinic.
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