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2016 ; 12
(1
): 44-46
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A Rare Breast Tumor: Dermatofibrosarcoma Protuberans
#MMPMID28331730
Özcan TB
; Hac?hasano?lu E
; Nazl? MA
; Aksoy ?
; Leblebici C
; Talu CK
J Breast Health
2016[Jan]; 12
(1
): 44-46
PMID28331730
show ga
Dermatofibrosarcoma protuberans is a slow-growing, local aggressive fibrous tumor
of the subcutaneous tissue, frequently seen in the proximal extremities and the
trunk. Its occurrence in the breast is very rare. Herein, we present a female who
presented with a breast mass, and aim to discuss pathological features and
differential diagnosis of dermatofibrosarcoma protuberans. A 44-year-old female
presented to our clinic with a mass on her breast. Physical examination revealed
a 8×5.5 cm mass with multilobular nodules on the skin in the lower inner quadrant
of her right breast. Her mammography revealed a hyperdense, 7.5×6.5 cm,
well-demarcated, lobulated mass in the right breast, which caused nodules on the
lower para-areolar portion of the breast skin. There was no axillary
lymphadenopathy on both clinical and radiologic examinations. A core needle
biopsy had been performed prior to her referral to our center, which revealed a
'spindle cell lesion'. The patient underwent simple mastectomy. On macroscopic
examination; the skin over the lesion appeared ulcerated, and there was a
well-defined solid mass, which was pale white-tan on the cut surface. Microscopic
examination revealed monotonous spindle cell proliferation arranged in storiform
pattern within the collagenous stroma with irregular extensions into deep adipose
tissue. There were no necrosis or nuclear pleomorphism. The mitotic rate was
2-3/10 HPF. Immunohistochemically tumor cells showed diffuse CD34 positivity, and
S100, EMA and SMA negativity. Based on histopathological and immunohistochemical
findings, the lesion was diagnosed as dermatofibrosarcoma protuberans. Local
recurrence is expected in 20-50% of these cases. Its treatment requires complete
surgical excision with wide margins. Distant metastases, although rare, have been
reported.