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10.1016/j.cell.2017.02.007

http://scihub22266oqcxt.onion/10.1016/j.cell.2017.02.007
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suck abstract from ncbi


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pmid28340338
      Cell 2017 ; 169 (1 ): 13-23
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  • A Phase Separation Model for Transcriptional Control #MMPMID28340338
  • Hnisz D ; Shrinivas K ; Young RA ; Chakraborty AK ; Sharp PA
  • Cell 2017[Mar]; 169 (1 ): 13-23 PMID28340338 show ga
  • Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains established and recently described features of transcriptional control. These features include the formation of super-enhancers, the sensitivity of super-enhancers to perturbation, the transcriptional bursting patterns of enhancers, and the ability of an enhancer to produce simultaneous activation at multiple genes. This model provides a conceptual framework to further explore principles of gene control in mammals.
  • |*Gene Expression Regulation [MESH]
  • |*Models, Biological [MESH]
  • |*Transcription, Genetic [MESH]
  • |Animals [MESH]
  • |Enhancer Elements, Genetic [MESH]
  • |Eukaryotic Cells/metabolism [MESH]
  • |Humans [MESH]
  • |Transcription Factors/metabolism [MESH]


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