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2017 ; 169
(1
): 13-23
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A Phase Separation Model for Transcriptional Control
#MMPMID28340338
Hnisz D
; Shrinivas K
; Young RA
; Chakraborty AK
; Sharp PA
Cell
2017[Mar]; 169
(1
): 13-23
PMID28340338
show ga
Phase-separated multi-molecular assemblies provide a general regulatory mechanism
to compartmentalize biochemical reactions within cells. We propose that a phase
separation model explains established and recently described features of
transcriptional control. These features include the formation of super-enhancers,
the sensitivity of super-enhancers to perturbation, the transcriptional bursting
patterns of enhancers, and the ability of an enhancer to produce simultaneous
activation at multiple genes. This model provides a conceptual framework to
further explore principles of gene control in mammals.