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2017 ; 120
(7
): 1063-1065
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A New Approach to PCSK9 Therapeutics
#MMPMID28264867
Wang N
; Tall AR
Circ Res
2017[Mar]; 120
(7
): 1063-1065
PMID28264867
show ga
PCSK9 inhibition is an effective therapy to reduce LDL cholesterol (LDL-C) and
cardiovascular events. A recent study shows that one or two doses of inclisiran,
a long-acting synthetic small-interfering RNA (siRNA) that selectively targets
hepatic PCSK9, causes a sustained reduction of plasma LDL-C for up to 6 months.
Pending further studies of safety and efficacy, this may represent an important
addition to the armamentarium for inhibiting PCSK9.