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2016 ; 63
(3
): 397-407
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A Long Noncoding RNA Regulates Sister Chromatid Cohesion
#MMPMID27477908
Marchese FP
; Grossi E
; Marín-Béjar O
; Bharti SK
; Raimondi I
; González J
; Martínez-Herrera DJ
; Athie A
; Amadoz A
; Brosh RM Jr
; Huarte M
Mol Cell
2016[Aug]; 63
(3
): 397-407
PMID27477908
show ga
Long noncoding RNAs (lncRNAs) are involved in diverse cellular processes through
multiple mechanisms. Here, we describe a previously uncharacterized human lncRNA,
CONCR (cohesion regulator noncoding RNA), that is transcriptionally activated by
MYC and is upregulated in multiple cancer types. The expression of CONCR is cell
cycle regulated, and it is required for cell-cycle progression and DNA
replication. Moreover, cells depleted of CONCR show severe defects in sister
chromatid cohesion, suggesting an essential role for CONCR in cohesion
establishment during cell division. CONCR interacts with and regulates the
activity of DDX11, a DNA-dependent ATPase and helicase involved in DNA
replication and sister chromatid cohesion. These findings unveil a direct role
for an lncRNA in the establishment of sister chromatid cohesion by modulating
DDX11 enzymatic activity.
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