Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27473322
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27473322
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cereb+Cortex
2016 ; 26
(10
): 3921-3927
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
A Hedonism Hub in the Human Brain
#MMPMID27473322
Zacharopoulos G
; Lancaster TM
; Bracht T
; Ihssen N
; Maio GR
; Linden DEJ
Cereb Cortex
2016[Oct]; 26
(10
): 3921-3927
PMID27473322
show ga
Human values are abstract ideals that motivate behavior. The motivational nature
of human values raises the possibility that they might be underpinned by brain
structures that are particularly involved in motivated behavior and reward
processing. We hypothesized that variation in subcortical hubs of the reward
system and their main connecting pathway, the superolateral medial forebrain
bundle (slMFB) is associated with individual value orientation. We conducted
Pearson's correlation between the scores of 10 human values and the volumes of 14
subcortical structures and microstructural properties of the medial forebrain
bundle in a sample of 87 participants, correcting for multiple comparisons
(i.e.,190). We found a positive association between the value that people attach
to hedonism and the volume of the left globus pallidus (GP).We then tested
whether microstructural parameters (i.e., fractional anisotropy and myelin volume
fraction) of the slMFB, which connects with the GP, are also associated to
hedonism and found a significant, albeit in an uncorrected level, positive
association between the myelin volume fraction within the left slMFB and hedonism
scores. This is the first study to elucidate the relationship between the
importance people attach to the human value of hedonism and structural variation
in reward-related subcortical brain regions.