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A Comparison of Two Mouse Frailty Assessment Tools
#MMPMID28549083
Kane AE
; Huizer-Pajkos A
; Mach J
; Mitchell SJ
; de Cabo R
; Le Couteur DG
; Howlett SE
; Hilmer SN
J Gerontol A Biol Sci Med Sci
2017[Jul]; 72
(7
): 904-909
PMID28549083
show ga
The mouse clinical frailty index and the mouse frailty phenotype assessment are
two recently developed tools used to assess frailty in mice. The objectives of
this study were to investigate whether the same mice are identified as frail with
both tools and to examine the association of each of the assessment tools with
age and frailty-related outcomes. Frailty was measured using both tools in old
(~24 months; n = 36) C57BL/6 male mice. After 2 weeks, blood pressure and heart
rate were measured and serum samples were collected for analysis of alanine
aminotransferase, creatinine, and albumin levels. The mouse frailty phenotype
assessment identified no mice as frail but modification of the assessment tool
identified six mice as frail. The mouse clinical frailty index identified 16 mice
as frail and the agreement between the two scales was 50.0%. Increasing clinical
frailty index scores were correlated with low serum alanine aminotransferase, as
well as decreased heart rate, and reduced heart rate variance. We conclude that,
consistent with equivalent frailty assessment scales in humans, both tools have
value but do not necessarily identify the same mice as frail.
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