Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26412854
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 EMBO+Rep
2015 ; 16
(11
): 1520-34
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
A BRCA1-interacting lncRNA regulates homologous recombination
#MMPMID26412854
Sharma V
; Khurana S
; Kubben N
; Abdelmohsen K
; Oberdoerffer P
; Gorospe M
; Misteli T
EMBO Rep
2015[Nov]; 16
(11
): 1520-34
PMID26412854
show ga
Long non-coding RNAs (lncRNAs) are important players in diverse biological
processes. Upon DNA damage, cells activate a complex signaling cascade referred
to as the DNA damage response (DDR). Using a microarray screen, we identify here
a novel lncRNA, DDSR1 (DNA damage-sensitive RNA1), which is induced upon DNA
damage. DDSR1 induction is triggered in an ATM-NF-?B pathway-dependent manner by
several DNA double-strand break (DSB) agents. Loss of DDSR1 impairs cell
proliferation and DDR signaling and reduces DNA repair capacity by homologous
recombination (HR). The HR defect in the absence of DDSR1 is marked by aberrant
accumulation of BRCA1 and RAP80 at DSB sites. In line with a role in regulating
HR, DDSR1 interacts with BRCA1 and hnRNPUL1, an RNA-binding protein involved in
DNA end resection. Our results suggest a role for the lncRNA DDSR1 in modulating
DNA repair by HR.
free
free
free
