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2018 ; 10
(ä): 1758835918780140
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5-fluorouracil and cardiotoxicity: a review
#MMPMID29977352
Sara JD
; Kaur J
; Khodadadi R
; Rehman M
; Lobo R
; Chakrabarti S
; Herrmann J
; Lerman A
; Grothey A
Ther Adv Med Oncol
2018[]; 10
(ä): 1758835918780140
PMID29977352
show ga
Fluoropyrimidines such as 5-fluorouracil (5-FU) form the foundation of a wide
variety of chemotherapy regimens. 5-FU is in fact the third most commonly used
chemotherapeutic agent in the treatment of solid malignancies across the world.
As with all chemotherapy, balancing the potential benefits of therapy against the
risks of drug-related toxicity is crucial when clinicians and patients make
shared decisions about treatment. 5-FU is the second most common chemotherapeutic
drug associated with cardiotoxicity after anthracyclines, which can manifest as
chest pain, acute coronary syndrome/myocardial infarction or death. Nevertheless
a widespread appreciation of 5-FU-related cardiotoxicity and its implications is
lacking amongst clinicians. In this review, we outline the incidence, possible
risk factors, and likely pathophysiological mechanisms that may account for
5-FU-related cardiotoxicity and also highlight potential management strategies
for this poorly understood clinical entity.