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40 Years of Research Put p53 in Translation
#MMPMID29883412
Marcel V
; Nguyen Van Long F
; Diaz JJ
Cancers (Basel)
2018[May]; 10
(5
): ? PMID29883412
show ga
Since its discovery in 1979, p53 has shown multiple facets. Initially the tumor
suppressor p53 protein was considered as a stress sensor able to maintain the
genome integrity by regulating transcription of genes involved in cell cycle
arrest, apoptosis and DNA repair. However, it rapidly came into light that p53
regulates gene expression to control a wider range of biological processes
allowing rapid cell adaptation to environmental context. Among them, those
related to cancer have been extensively documented. In addition to its role as
transcription factor, scattered studies reported that p53 regulates miRNA
processing, modulates protein activity by direct interaction or exhibits
RNA-binding activity, thus suggesting a role of p53 in regulating several layers
of gene expression not restricted to transcription. After 40 years of research,
it appears more and more clearly that p53 is strongly implicated in translational
regulation as well as in the control of the production and activity of the
translational machinery. Translation control of specific mRNAs could provide yet
unsuspected capabilities to this well-known guardian of the genome.
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