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2015 ; 9
(ä): 18
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3D-printer visualization of neuron models
#MMPMID26175684
McDougal RA
; Shepherd GM
Front Neuroinform
2015[]; 9
(ä): 18
PMID26175684
show ga
Neurons come in a wide variety of shapes and sizes. In a quest to understand this
neuronal diversity, researchers have three-dimensionally traced tens of thousands
of neurons; many of these tracings are freely available through online
repositories like NeuroMorpho.Org and ModelDB. Tracings can be visualized on the
computer screen, used for statistical analysis of the properties of different
cell types, used to simulate neuronal behavior, and more. We introduce the use of
3D printing as a technique for visualizing traced morphologies. Our method for
generating printable versions of a cell or group of cells is to expand dendrite
and axon diameters and then to transform the tracing into a 3D object with a
neuronal surface generating algorithm like Constructive Tessellated Neuronal
Geometry (CTNG). We show that 3D printed cells can be readily examined,
manipulated, and compared with other neurons to gain insight into both the
biology and the reconstruction process. We share our printable models in a new
database, 3DModelDB, and encourage others to do the same with cells that they
generate using our code or other methods. To provide additional context,
3DModelDB provides a simulatable version of each cell, links to papers that use
or describe it, and links to associated entries in other databases.
free
free
free
