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10.1093/nar/gkw1155 http://scihub22266oqcxt.onion/10.1093/nar/gkw1155 C5430849!5430849 !28180292     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28180292 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleic+Acids+Res 2017 ; 45 (3 ): 1049-1058 Nephropedia Template TP {{tp|p=28180292 |t=2017. 3D genome structure modeling by Lorentzian objective function |pdf=|usr=}}{{28180292 }} gab.com Text 3D genome structure modeling by Lorentzian objective function JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28180292 #FOAvip The 3D structure of the genome plays a vital role in biological processes such as gene interaction, gene regulation, DNA replication and genome methylation. Advanced chromosomal conformation capture techniques, such as Hi-C and tethered conformation capture, can generate chromosomal contact data that can be used to computationally reconstruct 3D structures of the genome. We developed a novel restraint-based method that is capable of reconstructing 3D genome structures utilizing both intra-and inter-chromosomal contact data. Our method was robust to noise and performed well in comparison with a panel of existing methods on a controlled simulated data set. On a real Hi-C data set of the human genome, our method produced chromosome and genome structures that are consistent with 3D FISH data and known knowledge about the human chromosome and genome, such as, chromosome territories and the cluster of small chromosomes in the nucleus center with the exception of the chromosome 18. The tool and experimental data are available at https://missouri.box.com/v/LorDG. Twit Text FOAVip 3D genome structure modeling by Lorentzian objective function ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28180292 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28180292 #FOAvip English Wikipedia <ref>{{Cite pmid|28180292 }}</ref> 3D genome structure modeling by Lorentzian objective function #MMPMID28180292 Trieu T ; Cheng J Nucleic Acids Res 2017[Feb]; 45 (3 ): 1049-1058 PMID28180292 show ga The 3D structure of the genome plays a vital role in biological processes such as gene interaction, gene regulation, DNA replication and genome methylation. Advanced chromosomal conformation capture techniques, such as Hi-C and tethered conformation capture, can generate chromosomal contact data that can be used to computationally reconstruct 3D structures of the genome. We developed a novel restraint-based method that is capable of reconstructing 3D genome structures utilizing both intra-and inter-chromosomal contact data. Our method was robust to noise and performed well in comparison with a panel of existing methods on a controlled simulated data set. On a real Hi-C data set of the human genome, our method produced chromosome and genome structures that are consistent with 3D FISH data and known knowledge about the human chromosome and genome, such as, chromosome territories and the cluster of small chromosomes in the nucleus center with the exception of the chromosome 18. The tool and experimental data are available at https://missouri.box.com/v/LorDG. |*Genome, Human [MESH] |Chromosomes, Human/genetics/*ultrastructure [MESH] |Computational Biology [MESH] |Databases, Genetic [MESH] |Genomics/methods/statistics & numerical data [MESH] |Humans [MESH] |Imaging, Three-Dimensional [MESH] |In Situ Hybridization, Fluorescence [MESH] |Models, Molecular [MESH]3D genome structure modeling by Lorentzian objective function (epmc).pdf DeepDyve Pubget Overpricing