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2016 ; 34
(4
): 422-434
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3D bioprinting for engineering complex tissues
#MMPMID26724184
Mandrycky C
; Wang Z
; Kim K
; Kim DH
Biotechnol Adv
2016[Jul]; 34
(4
): 422-434
PMID26724184
show ga
Bioprinting is a 3D fabrication technology used to precisely dispense cell-laden
biomaterials for the construction of complex 3D functional living tissues or
artificial organs. While still in its early stages, bioprinting strategies have
demonstrated their potential use in regenerative medicine to generate a variety
of transplantable tissues, including skin, cartilage, and bone. However, current
bioprinting approaches still have technical challenges in terms of
high-resolution cell deposition, controlled cell distributions, vascularization,
and innervation within complex 3D tissues. While no one-size-fits-all approach to
bioprinting has emerged, it remains an on-demand, versatile fabrication technique
that may address the growing organ shortage as well as provide a high-throughput
method for cell patterning at the micrometer scale for broad biomedical
engineering applications. In this review, we introduce the basic principles,
materials, integration strategies and applications of bioprinting. We also
discuss the recent developments, current challenges and future prospects of 3D
bioprinting for engineering complex tissues. Combined with recent advances in
human pluripotent stem cell technologies, 3D-bioprinted tissue models could serve
as an enabling platform for high-throughput predictive drug screening and more
effective regenerative therapies.